She slid the needle out of my forearm and pressed a cotton ball in firmly. A tiny red bubble leaked out before she reached it. The cotton slurped it up.
"It's inside you now," she said.
I shuddered. I had not expected a remark like that, or the fleeting panic it set off.
I had just enrolled in an HIV vaccine study. It was a Phase III trial, overseen by the NIH and CDC, which meant it had already proven safe
—now we were proving efficacy.
We—I liked that. Except we were disproving efficacy, more likely.
The consent form ran more than twenty pages. I read every line. I needed to be sure. My counselor was thorough, knowledgeable and caring. She was not letting me sign until I demonstrated I understood all the risks. Honestly though, they were minimal. I really wasn't worried at all.
Until she injected that first dose into my vein. And muttered the obvious.
God. Something was alive inside me. Tiny strands of DNA were making their way up my arm, toward my heart, to be pumped through every living tissue in my body. The DNA was manufactured synthetically, but identical in outward appearance to the deadly virus. Close enough to fool my body, hopefully. But inert, so it wouldn't kill me.
The side effects, if I had any, were due within 48 hours. Possibilities included nausea, mild fever, and a sore throat. Those were signals my immune system had ramped into overdrive. My throat would ache because the lymph nodes there had swollen to full capacity to pump out killer T-cells and macrophages to battle some disturbing invasion. All-out war raging inside my bloodstream.
How much of that shit had they injected? Enough to scare the hell out of my immune system. They hoped. Enough to prepare my body for the real virus a year or two or ten down the road if I did something really stupid.
It failed. That first injection was ten years ago, at Denver Health Medical Center. AidsVax was the most promising AIDS vaccine ever, the first to reach Phase III. I spent three years in the study, got a fresh injection and a free HIV test and a lot of counseling every six months. In February 2003, two decades into the search for a vaccine, VaxGen, the company that had developed the concoction
announced its results. No statistical impact.
Today, Kiwan, a very professional counselor at
Project Achieve in the East Village in New York City, slipped a fresh needle into my arm.